Parkinson’s disease (fluttering paralysis) – degenerative neurological pathology.
The nature of the disease is associated with several factors:
- Malfunctions within nerve cells: for example, due to injury or complications after infectious diseases of the brain.
- Disorders in the body against the background of interaction with harmful chemicals.
- Mutations in genes.
- With the accumulation of special presynaptic proteins in nerve cells – alpha-sinucleins.
Alpha-sinuclein proteins is produced by the nervous system itself. With a large accumulation, they become toxic and poison the brain. Human nerve cells begin to die, and the production of such an extremely important hormone as dopamine is significantly impaired. But it depends on the dopamine whether the person is able to learn, whether he can easily remember information and even hold a pen or pencil. The quality of sleep, the ability to concentrate, and the coordination of movements all depend on the same hormone. If dopamine in the body becomes scarce, the processes associated with thinking and motor activity are significantly slowed down.
Nowadays Parkinson’s disease is diagnosed more often than 50 years ago. But this is not due to the fact that the disease is progressing, but to the fact that people are more likely to get it after 50-60 years, and even more often 70-80 years. As life expectancy has increased over the last half a century, the number of people diagnosed with this disease has also increased. At present, about 1% of the world population suffers from Parkinson’s disease. But the disease of the elderly can not be called a pathology. People under the age of 50 may also suffer from Parkinson’s disease. As a percentage – the number of people sick is many times less, but people in the 20-40 years may also suffer from this disease. Also it is impossible to assert that Parkinson’s disease is a professional disease of people of certain professions. But the practice shows: there are areas in which you can often meet people with Parkinson’s disease. These are mining in mines and work with pesticides, agrochemicals.
The most common cause of the pathology is heredity. Cell death is associated with the activation of apotosis, a mechanism that is programmed genetically. 20% of patients with Parkinson’s disease have or had relatives who are familiar with this disease. In the risk group – persons with changes in one of the genes (PARK2 gene). The essential problem is that the disease transmission through the genes is autosomal recessive, which means that it usually manifests not directly from parents to children, but through a generation or even several generations. And many people are not aware of the danger, but if there was a person who suffered from this disease, there should be regular examinations of the organism in the neurological “slice”: especially after 50 years.
But besides the hereditary factor, there are other provocateurs of the disease:
- Taking a number of medicines. Practice shows that the disease may be caused by antidepressants of neuroleptics (methoklopramid), reserve, calcium antagonists (diltiazem), and lithium preparations. That is why these drugs are prescription ones and their administration requires strict control by a doctor. However, if the drugs were really dangerous, of course, no one would prescribe them. Everything is very individual.
- All kinds of injuries (especially dangerous concussions).
- Encephalitis – no matter what nature they have – viral or bacterial. In both cases there is a high risk of damage to the structure of vegetative ganglia – clusters of multipolar nerve cells.
- Other diseases. The provocateurs may be malignant formations, endocrine pathologies, atherosclerosis.