It is undetermined what causes Parkinsonís disease, or why you may develop Parkinsonís but the reasons are likely environmental and/or genetic. It is suggested that cell death may occur from oxidative stress, mitochondrial dysfunction and excitoxicity.
Oxidative damage Ė it is suggested that free radicals, which are unstable molecules having toxic effects that may be the result of oxidation and these in turn may contribute to cell death and Parkinsonís disease. It is thought that oxidation contributes to damage of tissues, including neurons.
Antioxidants appear to be extremely low in the brain of persons afflicted with Parkinsonís disease. Much reduced levels of Glutathione, which is an important antioxidant, show up in the diagnosis of Parkinsonís.
Mitochondrial dysfunction Ė mitochondria Ė small energy producing bodies within cells which may now have a reduced effectiveness could be a further source of Parkinsonís.
Excitotoxicity - when certain neurotransmitters in the brain go out of balance it can lead to cell death. Correcting the causes of imbalance in these neurotransmitters can likely protect them.
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